Role of acetylcholinesterase in lung cancer
نویسندگان
چکیده
Acetylcholinesterase (AChE) plays a key role in catalytic hydrolysis of cholinergic neurotransmitters. Intensive research has proven the involvement of this protein in novel functions, such as cell adhesion, differentiation, and proliferation. In addition, several recent studies have indicated that acetylcholinesterase is potentially a marker and regulator of apoptosis. Importantly, AChE is also a promising tumor suppressor. In this review, we briefly summarize the involvement of AChE in apoptosis and cancer, focusing on the role of AChE in lung cancer, as well as the therapeutic consideration of AChE for cancer therapy.
منابع مشابه
Role of Adenosine receptor in lung cancer
Summary: Adenosine through adenosine receptor have a crucial role in biology of lung cancer. Recent study indicated adenosine receptors have a crucial role in various aspect of lung cancer from cell growth and metastasis to modulation of apoptosis and it could be considered as a potential candidate for treatment of the lung cancer.
متن کاملA review of the role of dopamine receptors and novel therapeutic strategies in non-small cell lung cancer (NSCLC)
Lung cancer is a very aggressive and most deadly cancer in both men and women. Lung cancer is divided into two types of small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). NSCLC is divided into 3 subgroups: adenocarcinoma (AC), squamous cell carcinoma (SqCC) and large cell carcinoma (LCC). Dopamine is involved in controlling motions, cognition, emotions, memory and reward mech...
متن کاملDetection of lung cancer using CT images based on novel PSO clustering
Lung cancer is one of the most dangerous diseases that cause a large number of deaths. Early detection and analysis can be very helpful for successful treatment. Image segmentation plays a key role in the early detection and diagnosis of lung cancer. K-means algorithm and classic PSO clustering are the most common methods for segmentation that have poor outputs. In t...
متن کاملاستفاده از روشهای جراحی در مرحلهبندی سرطان ریه و تاثیر آن در انتخاب نوع درمان درصد بیمار مبتلا به سرطان ریه در بیمارستان امام خمینی تبریز
Background and Objective: Lung cancer is the leading cancer killer and is the second most frequently diagnosed cancer behind prostate in men and breast cancer in women. Staging has a very important role in determination of disease extension and therefore in deciding about the kind of treatment. The aim of this study is showing the effect of surgical method in lung cancer staging and its impact ...
متن کاملThe role and mechanisms of zinc oxide nanoparticles in the improvement of the radiosensitivity of lung cancer cells in clinically relevant megavoltage radiation energies in-vitro
Objective(s): Semiconductor zinc oxide nanoparticles (ZnO NPs) have unique properties, such as inherent selectivity and photosensitization effects under ultraviolet (UV) radiation. ZnO NPs serve as promising anticancer agents. However, UV radiation limits their penetration into the body. In most clinical settings, it is essential to use high-energy photons in the treatment of deep-seated tumors...
متن کامل